Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J, Porreca F, Makriyannis A, Malan TP, Jr. (2003) Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A 100: 10529-10533
Ige AO, Bolam JP, Billinton A, White JH, Marshall FH, Emson PC (2000) Cellular and sub-cellular localisation of GABA(B1) and GABA(B2) receptor proteins in the rat cerebellum. Brain Res Mol Brain Res 83: 72-80
Iglesias Niubo J, Riudor Taravilla E, Goma Brufau AR, Civit Colas MA, Sune Gracia JM, Bertran Sanges JM, Gallart Catala A (1988) [Sepsis, as the presenting form of hereditary tyrosinemia type I]. An Esp Pediatr 29: 235-238
Ihrig I, Schonheit C, Haussner W, Bernhardt I (1992) Characterisation of the potassium influx in rat erythrocytes. Gen Physiol Biophys 11: 377-388
Imagawa T, Smith JS, Coronado R, Campbell KP (1987) Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel. J Biol Chem 262: 16636-16643
Innis CA, Shi J, Blundell TL (2000) Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng 13: 839-847
Inui A (2002) Emesis, appetite, and endocannabinoids. Gastroenterology 123: 655; author reply 655-656
Ireland DC, Bord S, Beavan SR, Compston JE (2002) Effects of estrogen on collagen synthesis by cultured human osteoblasts depend on the rate of cellular differentiation. J Cell Biochem 86: 251-257
Irvine R (2001) Inositol phosphates: Does IP(4) run a protection racket? Curr Biol 11: R172-174
Irving AJ, Rae MG, Coutts AA (2002) Cannabinoids on the brain. ScientificWorldJournal 2: 632-648
Ishac EJ, Jiang L, Lake KD, Varga K, Abood ME, Kunos G (1996) Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves. Br J Pharmacol 118: 2023-2028
Ishii I, Chun J (2002) Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. Neuroreport 13: 593-596
Ishioka N, Bukoski RD (1999) A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation. J Pharmacol Exp Ther 289: 245-250
Islam TC, Asplund AC, Lindvall JM, Nygren L, Liden J, Kimby E, Christensson B, Smith CI, Sander B (2003) High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. Leukemia 17: 1880-1890
Isles AR, Ma D, Milsom C, Skynner MJ, Cui W, Clark J, Keverne EB, Allen ND (2001) Conditional ablation of neurones in transgenic mice. J Neurobiol 47: 183-193
Isokawa M, Alger BE (2003) Ryanodine receptor regulates calcium dependence of DSI in CA1 pyramidal cells of culture hippocampal slices. Society for Neuroscience Abstract Viewer and Itinerary Planner 2003
Iversen L (1994) Pharmacology. Endogenous cannabinoids. Nature 372: 619
Iversen L (2003) Cannabis and the brain. Brain 126: 1252-1270
Iversen LL (1993) Pharmacology. Medical uses of marijuana? Nature 365: 12-13
Iwai K, Nakahara C, Ando T (1971) Studies on protamines. XV. The complete amino acid sequence of the Z component of clupeine. Application of N leads to O acyl rearrangement and selective hydrolysis in sequence determination. J Biochem (Tokyo) 69: 493-509
Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T (2001) In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. J Pharmacol Exp Ther 296: 420-425
Iwatsuki N, Petersen OH (1978) Intracellular Ca2+ injection causes membrane hyperpolarization and conductance increase in lacrimal acinar cells. Pflugers Arch 377: 185-187
Izumi K, Sawada MT (2001) A novel assay method for glycosphingolipid deacylase by enzyme-linked immunochemical detection of lysoglycosphingolipid. Lipids 36: 97-101
Izzo AA, Borrelli F, Capasso F, Capasso R, Pinto L, Cristoni A, Mascolo N (1999) Contractile effect of (+)-glaucine in the isolated guinea-pig ileum. Eur J Pharmacol 377: 215-218
Izzo AA, Capasso F, Costagliola A, Bisogno T, Marsicano G, Ligresti A, Matias I, Capasso R, Pinto L, Borrelli F, Cecio A, Lutz B, Mascolo N, Di Marzo V (2003) An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. Gastroenterology 125: 765-774
Izzo AA, Capasso R, Pinto L, Di Carlo G, Mascolo N, Capasso F (2001) Effect of vanilloid drugs on gastrointestinal transit in mice. Br J Pharmacol 132: 1411-1416
Izzo AA, Fezza F, Capasso R, Bisogno T, Pinto L, Iuvone T, Esposito G, Mascolo N, Di Marzo V, Capasso F (2001) Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation. Br J Pharmacol 134: 563-570
Izzo AA, Mascolo N, Borrelli F, Capasso F (1998) Excitatory transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of cannabinoid CB1 receptors. Br J Pharmacol 124: 1363-1368
Izzo AA, Mascolo N, Borrelli F, Capasso F (1999) Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors. Naunyn Schmiedebergs Arch Pharmacol 359: 65-70
Izzo AA, Mascolo N, Capasso F (2000) Forgotten target for marijuana: the endocannabinoid system in the gut. Trends Pharmacol Sci 21: 372-373
Izzo AA, Mascolo N, Capasso F (2001) The gastrointestinal pharmacology of cannabinoids. Curr Opin Pharmacol 1: 597-603
Izzo AA, Mascolo N, Capasso R, Germano MP, De Pasquale R, Capasso F (1999) Inhibitory effect of cannabinoid agonists on gastric emptying in the rat. Naunyn Schmiedebergs Arch Pharmacol 360: 221-223
Izzo AA, Mascolo N, Pinto L, Capasso R, Capasso F (1999) The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats. Eur J Pharmacol 384: 37-42
Jack AM, Keegan A, Cotter MA, Cameron NE (2002) Effects of diabetes and evening primrose oil treatment on responses of aorta, corpus cavernosum and mesenteric vasculature in rats. Life Sci 71: 1863-1877
Jackson AP, Flett A, Smythe C, Hufton L, Wettey FR, Smythe E (2003) Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase. J Cell Biol 163: 231-236
Jackson MF, Orser BA, MacDonald JF (2001) Cannabinoids enhance the frequency of mEPSCs in cultured hippocampal neurons. Society for Neuroscience Abstracts 27
Jacobsson SO, Fowler CJ (2001) Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide. Br J Pharmacol 132: 1743-1754
Jacobsson SO, Rongard E, Stridh M, Tiger G, Fowler CJ (2000) Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability. Biochem Pharmacol 60: 1807-1813
Jacobsson SO, Wallin T, Fowler CJ (2001) Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 299: 951-959
Jacobsson SOP, Johansson M (2003) Neuronal differentiation of mouse P19 embryonic carcinoma cells induces expression of cannabinoid CB1 receptors. Society for Neuroscience Abstract Viewer and Itinerary Planner 2003
Jaggar SI, Hasnie FS, Sellaturay S, Rice AS (1998) The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain 76: 189-199
Jaggar SI, Sellaturay S, Rice AS (1998) The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. Neurosci Lett 253: 123-126
Jain MK, Ghomashchi F, Yu BZ, Bayburt T, Murphy D, Houck D, Brownell J, Reid JC, Solowiej JE, Wong SM, et al. (1992) Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2. J Med Chem 35: 3584-3586
Jain V, McWilliams E, Young M (2003) Thiomersal enhances the binding of histamine to the H1 receptor, but not histamine-stimulated inositol phosphate formation. J Pharm Pharmacol 55: 545-549
James JS (1996) Marijuana and chocolate. AIDS Treat News: 3-4
Jamshidi N, Taylor DA (2001) Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol 134: 1151-1154
Jan CR, Lu YC, Jiann BP, Chang HT, Su W, Chen WC, Huang JK (2002) Novel effect of CP55,940, a CB1/CB2 cannabinoid receptor agonist, on intracellular free Ca2+ levels in bladder cancer cells. Chin J Physiol 45: 33-39
Jan TR, Rao GK, Kaminski NE (2002) Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity. Mol Pharmacol 61: 446-454
Jarai Z, Kunos G (2002) [Cardiovascular effects of cannabinoids]. Orv Hetil 143: 1563-1568
Jarai Z, Wagner JA, Goparaju SK, Wang L, Razdan RK, Sugiura T, Zimmer AM, Bonner TI, Zimmer A, Kunos G (2000) Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice. Hypertension 35: 679-684
Jarai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, Zimmer AM, Bonner TI, Buckley NE, Mezey E, Razdan RK, Zimmer A, Kunos G (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci U S A 96: 14136-14141
Jarbe TU, Andrzejewski ME, DiPatrizio NV (2002) Interactions between the CB1 receptor agonist Delta 9-THC and the CB1 receptor antagonist SR-141716 in rats: open-field revisited. Pharmacol Biochem Behav 73: 911-919
Jarbe TU, DiPatrizio NV, Li C, Makriyannis A (2003) The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats. Pharmacol Biochem Behav 75: 809-821
Jarbe TU, Lamb RJ, Lin S, Makriyannis A (2000) Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats: a systematic replication. Behav Pharmacol 11: 81-86
Jarbe TU, Lamb RJ, Lin S, Makriyannis A (2001) (R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide. Psychopharmacology (Berl) 156: 369-380
Jarbe TU, Lamb RJ, Liu Q, Makriyannis A (2003) (R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A. Eur J Pharmacol 466: 121-127
Jarbe TU, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A (1998) Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology (Berl) 140: 519-522
Jarbe TU, Sheppard R, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A (1998) Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats. Behav Pharmacol 9: 169-174
Jarho P, Urtti A, Jarvinen K, Pate DW, Jarvinen T (1996) Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide. Life Sci 58: PL 181-185
Jarrahian A, Hillard CJ (1997) Arachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes. Prostaglandins Leukot Essent Fatty Acids 57: 551-554
Jarrahian A, Manna S, Edgemond WS, Campbell WB, Hillard CJ (2000) Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. J Neurochem 74: 2597-2606
Jarrahian A, Watts VJ, Barker EL (2004) D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptor. J Pharmacol Exp Ther 308: 880-886
Jarvinen T, Pate DW, Laine K (2002) Cannabinoids in the treatment of glaucoma. Pharmacol Ther 95: 203-220
Jbilo O, Derocq JM, Segui M, Le Fur G, Casellas P (1999) Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS Lett 448: 273-277
Jenkins DW, Feniuk W, Humphrey PP (2001) Characterization of the prostanoid receptor types involved in mediating calcitonin gene-related peptide release from cultured rat trigeminal neurones. Br J Pharmacol 134: 1296-1302
Jenkins DW, Sellers LA, Feniuk W, Humphrey PP (2003) Characterization of bradykinin-induced prostaglandin E2 release from cultured rat trigeminal ganglion neurones. Eur J Pharmacol 469: 29-36
Jennings EA, Vaughan CW, Roberts LA, Christie MJ (2003) The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. J Physiol 548: 121-129
Jeon YJ, Yang KH, Pulaski JT, Kaminski NE (1996) Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation. Mol Pharmacol 50: 334-341
Jerman JC, Gray J, Brough SJ, Ooi L, Owen D, Davis JB, Smart D (2002) Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors. Br J Anaesth 89: 882-887
Jia Y, McLeod RL, Wang X, Parra LE, Egan RW, Hey JA (2002) Anandamide induces cough in conscious guinea-pigs through VR1 receptors. Br J Pharmacol 137: 831-836
Jin KL, Mao XO, Goldsmith PC, Greenberg DA (2000) CB1 cannabinoid receptor induction in experimental stroke. Ann Neurol 48: 257-261
Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K (1999) Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. J Neurosci 19: 3773-3780
Jo YH, Role LW (2002) ENDOCANNABINOID RELEASE DEPRESSES GABAergic TRANSMISSION AT LH SYNAPSES IN MOUSE BRAIN SLICE PREPARATIONS. Society for Neuroscience Abstract Viewer and Itinerary Planner 2002
Johanek LM, Heitmiller DR, Turner M, Nader N, Hodges J, Simone DA (2001) Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms. Pain 93: 303-315
Johenning FW, Zochowski M, Conway SJ, Holmes AB, Koulen P, Ehrlich BE (2002) Distinct intracellular calcium transients in neurites and somata integrate neuronal signals. J Neurosci 22: 5344-5353
Johnson DE, Heald SL, Dally RD, Janis RA (1993) Isolation, identification and synthesis of an endogenous arachidonic amide that inhibits calcium channel antagonist 1,4-dihydropyridine binding. Prostaglandins Leukot Essent Fatty Acids 48: 429-437
Johnson KG, McKinnell IW, Stoker AW, Holt CE (2001) Receptor protein tyrosine phosphatases regulate retinal ganglion cell axon outgrowth in the developing Xenopus visual system. J Neurobiol 49: 99-117
Johnson RP, O'Kelly IM, Fearon IM (2004) System-specific O2 sensitivity of the tandem pore domain K+ channel TASK-1. Am J Physiol Cell Physiol 286: C391-397
Johnston AJ, Steiner LA, O'Connell M, Chatfield DA, Gupta AK, Menon DK (2004) Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients. Intensive Care Med 30: 45-50
Johnstrom P, Harris NG, Fryer TD, Barret O, Clark JC, Pickard JD, Davenport AP (2002) (18)F-Endothelin-1, a positron emission tomography (PET) radioligand for the endothelin receptor system: radiosynthesis and in vivo imaging using microPET. Clin Sci (Lond) 103 Suppl 48: 4S-8S
Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Makela R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W (1997) Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci 17: 1350-1362
Jones CA, Chessell IP, Simon J, Barnard EA, Miller KJ, Michel AD, Humphrey PP (2000) Functional characterization of the P2X(4) receptor orthologues. Br J Pharmacol 129: 388-394
Jones DB, Mullen KD, Roessle M, Maynard T, Jones EA (1987) Hepatic encephalopathy. Application of visual evoked responses to test hypotheses of its pathogenesis in rats. J Hepatol 4: 118-126
Jones DC, Young NT (2003) Natural killer receptor repertoires in transplantation. Eur J Immunogenet 30: 169-176
Jones RT (2002) Cardiovascular system effects of marijuana. J Clin Pharmacol 42: 58S-63S
Jones S, Howl J (2003) Cannabinoid receptor systems: therapeutic targets for tumour intervention. Expert Opin Ther Targets 7: 749-758
Jonsson KO, Andersson A, Jacobsson SO, Vandevoorde S, Lambert DM, Fowler CJ (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol 77: 201-207
Jonsson KO, Vandevoorde S, Lambert DM, Tiger G, Fowler CJ (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br J Pharmacol 133: 1263-1275
Joosten M, Valk PJ, Jorda MA, Vankan-Berkhoudt Y, Verbakel S, van den Broek M, Beijen A, Lowenberg B, Delwel R (2002) Leukemic predisposition of pSca-1/Cb2 transgenic mice. Exp Hematol 30: 142-149
Joosten M, Vankan-Berkhoudt Y, Tas M, Lunghi M, Jenniskens Y, Parganas E, Valk PJ, Lowenberg B, van den Akker E, Delwel R (2002) Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites. Oncogene 21: 7247-7255
Jorda MA, Lowenberg B, Delwel R (2003) The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation. Blood 101: 1336-1343
Jorda MA, Rayman N, Valk P, De Wee E, Delwel R (2003) Identification, characterization, and function of a novel oncogene - The peripheral cannabinoid receptor Cb2. Hematopoietic Stem Cells 2002: Genetics and Function 996: 10-16
Jorda MA, Rayman N, Valk P, De Wee E, Delwel R (2003) Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. Ann N Y Acad Sci 996: 10-16
Jorda MA, Verbakel S, van Ostaijen I, Lowenberg B, Delwel R (2002) The peripheral cannabinoid receptor is a myeloid transforming protein: Activation by CP55,940 ligand blocks neutrophilic development whereas the endocannabinoid 2-AG stimulates migration. Blood 100: 742a-743a
Jorda MA, Verbakel SE, Valk PJ, Vankan-Berkhoudt YV, Maccarrone M, Finazzi-Agro A, Lowenberg B, Delwel R (2002) Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. Blood 99: 2786-2793
Jorgensen TD, Dissing S, Gromada J (1996) Cyclic GMP potentiates phenylephrine but not cyclic ADP-ribose-evoked calcium release from rat lacrimal acinar cells. FEBS Lett 391: 117-120
Joseph J, Niggemann B, Zaenker KS, Entschladen F (2004) Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. Cancer Immunol Immunother
Joyeux M, Arnaud C, Godin-Ribuot D, Demenge P, Lamontagne D, Ribuot C (2002) Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts. Cardiovasc Res 55: 619-625
Julian MD, Martin AB, Cuellar B, Rodriguez De Fonseca F, Navarro M, Moratalla R, Garcia-Segura LM (2003) Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience 119: 309-318
Jung M (2001) Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem 8: 1505-1511
Jung M, Calassi R, Rinaldi-Carmona M, Chardenot P, Le Fur G, Soubrie P, Oury-Donat F (1997) Characterization of CB1 receptors on rat neuronal cell cultures: binding and functional studies using the selective receptor antagonist SR 141716A. J Neurochem 68: 402-409
Juntunen J, Huuskonen J, Laine K, Niemi R, Taipale H, Nevalainen T, Pate DW, Jarvinen T (2003) Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide. Eur J Pharm Sci 19: 37-43
Juntunen J, Vepsalainen J, Niemi R, Laine K, Jarvinen T (2003) Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether. J Med Chem 46: 5083-5086
Justinova Z, Tanda G, Munzar P, Goldberg SR (2004) The opioid antagonist naltrexone reduces the reinforcing effects of Delta(9)-tetrahydrocannabinol (THC) in squirrel monkeys. Psychopharmacology (Berl) 173: 186-194