Tada T, Tada M, Hilton K, Barton SC, Sado T, Takagi N, Surani MA (1998) Epigenotype switching of imprintable loci in embryonic germ cells. Dev Genes Evol 207: 551-561
Takahashi KA, Linden DJ (2000) Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells. J Neurophysiol 83: 1167-1180
Takahashi M, Kohara A, Shishikura J, Kawasaki-Yatsugi S, Ni JW, Yatsugi S, Sakamoto S, Okada M, Shimizu-Sasamata M, Yamaguchi T (2002) YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. CNS Drug Rev 8: 337-352
Takei K, Stukenbrok H, Metcalf A, Mignery GA, Sudhof TC, Volpe P, De Camilli P (1992) Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin. J Neurosci 12: 489-505
Takeo S, Takenaka F (1978) Comparison of myocardial and adipose tissue lipase activity in the rat. Jpn Heart J 19: 103-111
Tamalu F, Chiba C, Ishida AT, Saito T (2000) Functional differentiation of ganglion cells from multipotent progenitor cells in sliced retina of adult goldfish. J Comp Neurol 419: 297-305
Tan YP, Marty A (1991) Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells. J Physiol 433: 357-371
Tan YP, Marty A, Trautmann A (1992) High density of Ca(2+)-dependent K+ and Cl- channels on the luminal membrane of lacrimal acinar cells. Proc Natl Acad Sci U S A 89: 11229-11233
Tanda G, Goldberg SR (2003) Cannabinoids: reward, dependence, and underlying neurochemical mechanisms--a review of recent preclinical data. Psychopharmacology (Berl) 169: 115-134
Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348: 429-432
Tangkrisanavinont V, Pholpramool C (1979) Extracellular free calcium and fluid secretion by the rabbit lacrimal gland in vivo. Pflugers Arch 382: 275-277
Tanimura A, Tojyo Y, Matsumoto Y, Yajima T (1998) Imaging of calcium release in inositol 1,4,5-trisphosphate-sensitive internal stores in permeabilized HSY cells using fluorescent indicators. Cell Struct Funct 23: 1-7
Tao Q, Abood ME (1998) Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling. J Pharmacol Exp Ther 285: 651-658
Tao Q, McAllister SD, Andreassi J, Nowell KW, Cabral GA, Hurst DP, Bachtel K, Ekman MC, Reggio PH, Abood ME (1999) Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. Mol Pharmacol 55: 605-613
Tarzia G, Duranti A, Tontini A, Piersanti G, Mor M, Rivara S, Plazzi PV, Park C, Kathuria S, Piomelli D (2003) Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. J Med Chem 46: 2352-2360
Taylor CW (1998) Inositol trisphosphate receptors: Ca2+-modulated intracellular Ca2+ channels. Biochim Biophys Acta 1436: 19-33
Taylor CW, Genazzani AA, Morris SA (1999) Expression of inositol trisphosphate receptors. Cell Calcium 26: 237-251
Taylor CW, Laude AJ (2002) IP3 receptors and their regulation by calmodulin and cytosolic Ca2+. Cell Calcium 32: 321-334
Taylor CW, Thorn P (2001) Calcium signalling: IP3 rises again.and again. Curr Biol 11: R352-355
Teh YM, Neuberger MS (1997) The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice. J Exp Med 185: 1753-1758
Telemaque-Potts S, Kuc RE, Maguire JJ, Ohlstein E, Yanagisawa M, Davenport AP (2002) Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelin(A), but not endothelin(B), receptors in an animal model of hypertension. Clin Sci (Lond) 103 Suppl 48: 357S-362S
Tempia F, Konnerth A (1994) Calcium requirement of long-term depression and rebound potentiation in cerebellar Purkinje neurons. Semin Cell Biol 5: 243-250
Tepavcevic V, Hodges RR, Zoukhri D, Dartt DA (2003) Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland. Invest Ophthalmol Vis Sci 44: 1075-1081
Terranova JP, Michaud JC, Le Fur G, Soubrie P (1995) Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors. Naunyn Schmiedebergs Arch Pharmacol 352: 576-579
Terranova JP, Storme JJ, Lafon N, Perio A, Rinaldi-Carmona M, Le Fur G, Soubrie P (1996) Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716. Psychopharmacology (Berl) 126: 165-172
Thakur GA, Palmer SL, Harrington PE, Stergiades IA, Tius MA, Makriyannis A (2002) Enantiomeric resolution of a novel chiral cannabinoid receptor ligand. J Biochem Biophys Methods 54: 415-422
Thomas A, Ross RA, Saha B, Mahadevan A, Razdan RK, Pertwee RG (2004) 6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist. Eur J Pharmacol 487: 213-221
Thomas BF, Adams IB, Mascarella SW, Martin BR, Razdan RK (1996) Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore. J Med Chem 39: 471-479
Thomas BF, Gilliam AF, Burch DF, Roche MJ, Seltzman HH (1998) Comparative receptor binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther 285: 285-292
Thomas D, Lipp P, Berridge MJ, Bootman MD (1998) Hormone-evoked elementary Ca2+ signals are not stereotypic, but reflect activation of different size channel clusters and variable recruitment of channels within a cluster. J Biol Chem 273: 27130-27136
Thomas EA, Cravatt BF, Danielson PE, Gilula NB, Sutcliffe JG (1997) Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. J Neurosci Res 50: 1047-1052
Thomas LS, Jane DE, Harris JR, Croucher MJ (2000) Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro. Neuropharmacology 39: 1554-1566
Thompson AJ, Lummis SC (2003) A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor. Br J Pharmacol 140: 359-365
Thorig L, Van Haeringen NJ, Timmermans PB, Van Zwieten PA (1983) Peroxidase secretion from rat lacrimal gland cells in vitro: II. The role of calcium in stimulus-secretion coupling. Exp Eye Res 37: 485-492
Thorn P, Petersen OH (1993) Nonselective cation channels in exocrine gland cells. Exs 66: 185-200
Thorn P, Petersen OH (1994) A voltage-sensitive transient potassium current in mouse pancreatic acinar cells. Pflugers Arch 428: 288-295
Thrower EC, Mobasheri H, Dargan S, Marius P, Lea EJ, Dawson AP (2000) Interaction of luminal calcium and cytosolic ATP in the control of type 1 inositol (1,4,5)-trisphosphate receptor channels. J Biol Chem 275: 36049-36055
Thumser AE, Voysey J, Wilton DC (1997) A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis. Biochem Pharmacol 53: 433-435
Tiger G, Stenstrom A, Fowler CJ (2000) Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate. Biochem Pharmacol 59: 647-653
Tius MA, Hill WA, Zou XL, Busch-Petersen J, Kawakami JK, Fernandez-Garcia MC, Drake DJ, Abadji V, Makriyannis A (1995) Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain. Life Sci 56: 2007-2012
Toescu EC, Lawrie AM, Petersen OH, Gallacher DV (1992) Spatial and temporal distribution of agonist-evoked cytoplasmic Ca2+ signals in exocrine acinar cells analysed by digital image microscopy. Embo J 11: 1623-1629
Tognetto M, Amadesi S, Harrison S, Creminon C, Trevisani M, Carreras M, Matera M, Geppetti P, Bianchi A (2001) Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. J Neurosci 21: 1104-1109
Tong W, Collantes ER, Welsh WJ, Berglund BA, Howlett AC (1998) Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis. J Med Chem 41: 4207-4215
Topinka JR, Bredt DS (1998) N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Neuron 20: 125-134
Torres J, Briggs JA, Arkin IT (2002) Multiple site-specific infrared dichroism of CD3-zeta, a transmembrane helix bundle. J Mol Biol 316: 365-374
Toth A, Kedei N, Wang Y, Blumberg PM (2003) Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. Life Sci 73: 487-498
Touze T, Hayward RD, Eswaran J, Leong JM, Koronakis V (2004) Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptor. Mol Microbiol 51: 73-87
Tovey SC, de Smet P, Lipp P, Thomas D, Young KW, Missiaen L, De Smedt H, Parys JB, Berridge MJ, Thuring J, Holmes A, Bootman MD (2001) Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses. J Cell Sci 114: 3979-3989
Tovey SC, Goraya TA, Taylor CW (2003) Parathyroid hormone increases the sensitivity of inositol trisphosphate receptors by a mechanism that is independent of cyclic AMP. Br J Pharmacol 138: 81-90
Towler D, Glaser L (1986) Acylation of cellular proteins with endogenously synthesized fatty acids. Biochemistry 25: 878-884
Trautmann A, Marty A (1984) Activation of Ca-dependent K channels by carbamoylcholine in rat lacrimal glands. Proc Natl Acad Sci U S A 81: 611-615
Traynor D, Milne JL, Insall RH, Kay RR (2000) Ca(2+) signalling is not required for chemotaxis in Dictyostelium. Embo J 19: 4846-4854
Trettel J, Fortin DA, Levine ES (2004) Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex. J Physiol 556: 95-107
Trettel J, Levine ES (2002) Inhibitory Perisomatic Inputs to Neocortical Pyramidal Neurons Are Suppressed by Endogenous Cannabinoids. Society for Neuroscience Abstract Viewer and Itinerary Planner 2002
Trettel J, Levine ES (2003) Endocannabinoids mediate rapid retrograde signaling at interneuron -> pyramidal neuron synapses of the neocortex. Journal of Neurophysiology 89: 2334-2338
Trettel J, Levine ES (2003) Endocannabinoids mediate rapid retrograde signaling at interneuron fwdarw pyramidal neuron synapses of the neocortex. Journal of Neurophysiology (Bethesda) 89: 2334-2338
Trettel J, Levine ES (2003) Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex. J Neurophysiol 89: 2334-2338
Trettel J, Levine ES (2003) Retrograde signaling by endocannabinoids selectively targets perisomatic inhibitory inputs to pyramidal neurons of the neocortex. Society for Neuroscience Abstract Viewer and Itinerary Planner 2003
Tripathy A, Xu L, Pasek DA, Meissner G (1999) Effects of 2,3-butanedione 2-monoxime on Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle. J Membr Biol 169: 189-198
Tripathy S, Chapman KD, Dixon RA (2002) Identification and characterization of a binding protein for N-acylethanolamines in memebranes of tobacco cells. Plant Biology (Rockville) 2002
Tripathy S, Kleppinger-Sparace K, Dixon RA, Chapman KD (2003) N-acylethanolamine signaling in tobacco is mediated by a membrane-associated, high-affinity binding protein. Plant Physiol 131: 1781-1791
Tripathy S, Kleppinger-Sparace KF, Chapman KD, Dixon RA (2001) Evidence that N-Acylethanolamine signaling in tobacco is mediated by a cannabinoid receptor-like binding protein. Plant Biology (Rockville) 2001
Tripathy S, Venables BJ, Chapman KD (1999) N-Acylethanolamines in signal transduction of elicitor perception. Attenuation Of alkalinization response and activation of defense gene expression. Plant Physiol 121: 1299-1308
Trowsdale J (2001) Genetic and functional relationships between MHC and NK receptor genes. Immunity 15: 363-374
Tsai SJ, Wang YC, Hong CJ (2001) Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders. Am J Med Genet 105: 219-221
Tsou K, Brown S, Sanudo-Pena MC, Mackie K, Walker JM (1998) Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83: 393-411
Tsou K, Nogueron MI, Muthian S, Sanudo-Pena MC, Hillard CJ, Deutsch DG, Walker JM (1998) Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neurosci Lett 254: 137-140
Tsuboi K, Hilligsmann C, Vandevoorde S, Lambert DM, Ueda N (2004) N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem J 379: 99-106
Tucker RC, Kagaya M, Page CP, Spina D (2001) The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways. Br J Pharmacol 132: 1127-1135
Turner M (2002) B-cell development and antigen receptor signalling. Biochem Soc Trans 30: 812-815
Turner M, Billadeau DD (2002) VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol 2: 476-486
Twells RC, Mein CA, Payne F, Veijola R, Gilbey M, Bright M, Timms A, Nakagawa Y, Snook H, Nutland S, Rance HE, Carr P, Dudbridge F, Cordell HJ, Cooper J, Tuomilehto-Wolf E, Tuomilehto J, Phillips M, Metzker M, Hess JF, Todd JA (2003) Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes. Hum Genet 113: 99-105
Twells RC, Mein CA, Phillips MS, Hess JF, Veijola R, Gilbey M, Bright M, Metzker M, Lie BA, Kingsnorth A, Gregory E, Nakagawa Y, Snook H, Wang WY, Masters J, Johnson G, Eaves I, Howson JM, Clayton D, Cordell HJ, Nutland S, Rance H, Carr P, Todd JA (2003) Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene. Genome Res 13: 845-855
Twitchell W, Brown S, Mackie K (1997) Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 78: 43-50
Tyler K, Hillard CJ, Greenwood-Van Meerveld B (2000) Inhibition of small intestinal secretion by cannabinoids is CB1 receptor-mediated in rats. Eur J Pharmacol 409: 207-211
Tytgat J, Van Boven M, Daenens P (2000) Cannabinoid mimics in chocolate utilized as an argument in court. Int J Legal Med 113: 137-139
Tzavara ET, Davis RJ, Perry KW, Li X, Salhoff C, Bymaster FP, Witkin JM, Nomikos GG (2003) The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Br J Pharmacol 138: 544-553
Tzavara ET, Wade M, Nomikos GG (2003) Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action. J Neurosci 23: 9374-9384
Uchida Y, Hara M, Nishio H, Sidransky E, Inoue S, Otsuka F, Suzuki A, Elias PM, Holleran WM, Hamanaka S (2000) Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 41: 2071-2082
Ueda N (1995) [Anandamide: an endogenous cannabinoid receptor agonist]. Seikagaku 67: 1036-1040
Ueda N (1999) [Anandamide and its related compounds]. Tanpakushitsu Kakusan Koso 44: 1139-1145
Ueda N (2002) Endocannabinoid hydrolases. Prostaglandins Other Lipid Mediat 68-69: 521-534
Ueda N, Goparaju SK, Katayama K, Kurahashi Y, Suzuki H, Yamamoto S (1998) A hydrolase enzyme inactivating endogenous ligands for cannabinoid receptors. J Med Invest 45: 27-36
Ueda N, Katayama K, Goparaju SK, Kurahashi Y, Yamanaka K, Suzuki H, Yamamoto S (2002) Catalytic properties of purified recombinant anandamide amidohydrolase. Adv Exp Med Biol 507: 251-256
Ueda N, Katayama K, Kurahashi Y, Suzuki M, Suzuki H, Yamamoto S, Katoh I, Di Marzo V, De Petrocellis L (1999) Enzymological and molecular biological studies on anandamide amidohydrolase. Adv Exp Med Biol 469: 513-518
Ueda N, Kurahashi Y, Yamamoto K, Yamamoto S (1997) Anandamide amidohydrolase from porcine brain. Partial purification and characterization. Adv Exp Med Biol 407: 323-328
Ueda N, Kurahashi Y, Yamamoto K, Yamamoto S, Tokunaga T (1996) Enzymes for anandamide biosynthesis and metabolism. J Lipid Mediat Cell Signal 14: 57-61
Ueda N, Kurahashi Y, Yamamoto S, Tokunaga T (1995) Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide. J Biol Chem 270: 23823-23827
Ueda N, Liu Q, Yamanaka K (2001) Marked activation of the N-acylphosphatidylethanolamine-hydrolyzing phosphodiesterase by divalent cations. Biochim Biophys Acta 1532: 121-127
Ueda N, Yamamoto K, Kurahashi Y, Yamamoto S, Ogawa M, Matsuki N, Kudo I, Shinkai H, Shirakawa E, Tokunaga T (1995) Oxygenation of arachidonylethanolamide (anandamide) by lipoxygenases. Adv Prostaglandin Thromboxane Leukot Res 23: 163-165
Ueda N, Yamamoto K, Yamamoto S, Tokunaga T, Shirakawa E, Shinkai H, Ogawa M, Sato T, Kudo I, Inoue K, et al. (1995) Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonist. Biochim Biophys Acta 1254: 127-134
Ueda N, Yamamoto S (1995) [Anandamide: a marijuana-like compound produced in animal tissues]. Tanpakushitsu Kakusan Koso 40: 2329-2339
Ueda N, Yamamoto S (2000) Anandamide amidohydrolase (fatty acid amide hydrolase). Prostaglandins Other Lipid Mediat 61: 19-28
Ueda N, Yamanaka K, Katayama K, Goparaju SK, Suzuki H, Yamamoto S (2001) Alkaline and acid amidases hydrolyzing anandamide and other N-acylethanolamines. World Rev Nutr Diet 88: 215-222
Ueda N, Yamanaka K, Terasawa Y, Yamamoto S (1999) An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. FEBS Lett 454: 267-270
Ueda N, Yamanaka K, Yamamoto S (2001) Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. J Biol Chem 276: 35552-35557
Uehara A, Fill M, Velez P, Yasukochi M, Imanaga I (1996) Rectification of rabbit cardiac ryanodine receptor current by endogenous polyamines. Biophys J 71: 769-777
Ugdyzhekova DS, Bernatskaya NA, Stefano JB, Graier VF, Tam SW, Mekhoulam R (2001) Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors. Bull Exp Biol Med 131: 251-253
Ujike H, Takaki M, Nakata K, Tanaka Y, Takeda T, Kodama M, Fujiwara Y, Sakai A, Kuroda S (2002) CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia. Mol Psychiatry 7: 515-518
Ulfers AL, McMurry JL, Kendall DA, Mierke DF (2002) Structure of the third intracellular loop of the human cannabinoid 1 receptor. Biochemistry 41: 11344-11350
Ulfers AL, McMurry JL, Miller A, Wang L, Kendall DA, Mierke DF (2002) Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity. Protein Sci 11: 2526-2531
Undem BJ, Kollarik M (2002) Characterization of the vanilloid receptor 1 antagonist iodo-resiniferatoxin on the afferent and efferent function of vagal sensory C-fibers. J Pharmacol Exp Ther 303: 716-722
Unwin N (2003) Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Lett 555: 91-95
Unwin N, Miyazawa A, Li J, Fujiyoshi Y (2002) Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits. J Mol Biol 319: 1165-1176
Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Crawford RB, Kaminski NE (2003) Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. Int J Cancer 104: 12-18
Urban S, Brown G, Freeman M (2004) EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development 131: 1835-1845
Urban S, Lee JR, Freeman M (2001) Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107: 173-182
Urban S, Lee JR, Freeman M (2002) A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. Embo J 21: 4277-4286
Urban S, Schlieper D, Freeman M (2002) Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids. Curr Biol 12: 1507-1512
Urso B, Cope DL, Kalloo-Hosein HE, Hayward AC, Whitehead JP, O'Rahilly S, Siddle K (1999) Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes. J Biol Chem 274: 30864-30873
Urso B, Niesler CU, O'Rahilly S, Siddle K (2001) Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes. Cell Signal 13: 279-285
Uusisaari M, Smirnov S, Voipio J, Kaila K (2002) Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists. Neuropharmacology 43: 563-572
Vacca G, Serra S, Brunetti G, Carai MA, Gessa GL, Colombo G (2002) Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716. Eur J Pharmacol 445: 55-59
Valdivia HH, Kirby MS, Lederer WJ, Coronado R (1992) Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle. Proc Natl Acad Sci U S A 89: 12185-12189
Valenti M, Vigano D, Casico MG, Rubino T, Steardo L, Parolaro D, Di Marzo V (2004) Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain. Cell Mol Life Sci 61: 945-950
Vales-Gomez M, Browne H, Reyburn HT (2003) Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells. BMC Immunol 4: 4
Vales-Gomez M, Erskine RA, Deacon MP, Strominger JL, Reyburn HT (2001) The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins. Proc Natl Acad Sci U S A 98: 1734-1739
Valk P, Verbakel S, Vankan Y, Hol S, Mancham S, Ploemacher R, Mayen A, Lowenberg B, Delwel R (1997) Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. Blood 90: 1448-1457
Valk P, Verbakel S, von Lindern M, Lowenberg B, Delwel R (2000) Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2. Hematol J 1: 254-263
Valk PJ, Delwel R (1998) The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis. Leuk Lymphoma 32: 29-43
Valk PJ, Vankan Y, Joosten M, Jenkins NA, Copeland NG, Lowenberg B, Delwel R (1999) Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. J Virol 73: 3595-3602
Valverde O, Ledent C, Beslot F, Parmentier M, Roques BP (2000) Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors. Eur J Neurosci 12: 533-539
Van den Bossche I, Vanheel B (2000) Influence of cannabinoids on the delayed rectifier in freshly dissociated smooth muscle cells of the rat aorta. Br J Pharmacol 131: 85-93
Van der Aa F, Roskams T, Blyweert W, De Ridder D (2003) Interstitial cells in the human prostate: a new therapeutic target? Prostate 56: 250-255
Van der Kloot W (1994) Anandamide, a naturally-occurring agonist of the cannabinoid receptor, blocks adenylate cyclase at the frog neuromuscular junction. Brain Res 649: 181-184
Van der Kloot W, Benjamin WB, Balezina OP (1998) Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions. J Physiol 507 (Pt 3): 689-695
van der Stelt M, Di Marzo V (2003) The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders. Eur J Pharmacol 480: 133-150
Van Der Stelt M, Di Marzo V (2004) Endovanilloids. Eur J Biochem 271: 1827-1834
van der Stelt M, Hansen HH, Veldhuis WB, Bar PR, Nicolay K, Veldink GA, Vliegenthart JF, Hansen HS (2003) Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases. Neurotox Res 5: 183-200
van der Stelt M, Nieuwenhuizen WF, Veldink GA, Vliegenthart JF (1997) Dioxygenation of N-linoleoyl amides by soybean lipoxygenase-1. FEBS Lett 411: 287-290
Van Der Stelt M, Noordermeer MA, Kiss T, Van Zadelhoff G, Merghart B, Veldink GA, Vliegenthart JF (2000) Formation of a new class of oxylipins from N-acyl(ethanol)amines by the lipoxygenase pathway. Eur J Biochem 267: 2000-2007
van der Stelt M, Paoletti AM, Maccarrone M, Nieuwenhuizen WF, Bagetta G, Veldink GA, Finazzi Agro A, Vliegenthart JF (1997) The effect of hydroxylation of linoleoyl amides on their cannabinomimetic properties. FEBS Lett 415: 313-316
van der Stelt M, van Kuik JA, Bari M, van Zadelhoff G, Leeflang BR, Veldink GA, Finazzi-Agro A, Vliegenthart JF, Maccarrone M (2002) Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. J Med Chem 45: 3709-3720
van der Stelt M, Veldhuis WB, Maccarrone M, Bar PR, Nicolay K, Veldink GA, Di Marzo V, Vliegenthart JF (2002) Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Mol Neurobiol 26: 317-346
van der Stelt M, Veldhuis WB, van Haaften GW, Fezza F, Bisogno T, Bar PR, Veldink GA, Vliegenthart JF, Di Marzo V, Nicolay K (2001) Exogenous anandamide protects rat brain against acute neuronal injury in vivo. J Neurosci 21: 8765-8771
van der Stelt M, Veldhuis WB, Wadman MW, van Zadelhoff G, Fezza F, Veldink GA, Vliegenthart JFG, Bar PR, Nicolay K, Di Marzo V (2003) Mechanisms underlying in vivo neuroprotection by the endocannabinoid anandamide and the cannabinoid/vanilloid receptor agonist, arvanil. Journal of Neurochemistry 85: 6-6
Van Haeringen NJ, Ensink F, Glasius E (1975) Amylase in human tear fluid: origin and characteristics, compared with salivary and urinary amylases. Exp Eye Res 21: 395-403
van Pouderoyen G, Eggert T, Jaeger KE, Dijkstra BW (2001) The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J Mol Biol 309: 215-226
Van Sickle MD, Oland LD, Ho W, Hillard CJ, Mackie K, Davison JS, Sharkey KA (2001) Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. Gastroenterology 121: 767-774
Van Sickle MD, Oland LD, Mackie K, Davison JS, Sharkey KA (2003) Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. Am J Physiol Gastrointest Liver Physiol 285: G566-576
van Zadelhoff G, Veldink GA, Vliegenthart JF (1998) With anandamide as substrate plant 5-lipoxygenases behave like 11-lipoxygenases. Biochem Biophys Res Commun 248: 33-38
Vandevoorde S, Jonsson KO, Fowler CJ, Lambert DM (2003) Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide. J Med Chem 46: 1440-1448
Vandevoorde S, Lambert DM, Smart D, Jonsson KO, Fowler CJ (2003) N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity. Bioorg Med Chem 11: 817-825
Vandevoorde S, Tsuboi K, Ueda N, Jonsson KO, Fowler CJ, Lambert DM (2003) Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase. J Med Chem 46: 4373-4376
Vanheel B, Van de Voorde J (2001) Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries. J Pharmacol Exp Ther 296: 322-328
Vanlingen S, Sipma H, De Smet P, Callewaert G, Missiaen L, De Smedt H, Parys JB (2000) Ca2+ and calmodulin differentially modulate myo-inositol 1,4, 5-trisphosphate (IP3)-binding to the recombinant ligand-binding domains of the various IP3 receptor isoforms. Biochem J 346 Pt 2: 275-280
Vannacci A, Passani MB, Pierpaoli S, Giannini L, Mannaioni PF, Masini E (2003) Nitric oxide modulates the inhibitory effect of cannabinoids on the immunological activation of guinea pig mast cells. Inflamm Res 52 Suppl 1: S07-08
Vannacci A, Zagli G, Marzocca C, Pierpaoli S, Passani MB, Mannaioni PF, Masini E (2002) Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cells. Inflamm Res 51 Suppl 1: S09-10
Varga K, Lake K, Martin BR, Kunos G (1995) Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide. Eur J Pharmacol 278: 279-283
Varga K, Lake KD, Huangfu D, Guyenet PG, Kunos G (1996) Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension 28: 682-686
Varga K, Wagner JA, Bridgen DT, Kunos G (1998) Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. Faseb J 12: 1035-1044
Varma N, Brager D, Morishita W, Lenz RA, London B, Alger B (2002) Presynaptic factors in the regulation of DSI expression in hippocampus. Neuropharmacology 43: 550-562
Varma N, Brager DH, Morishita W, Lenz RA, London B, Alger B (2002) Presynaptic factors in the regulation of DST expression in hippocampus. Neuropharmacology 43: 550-562
Varma N, Carlson G, Wang Y, Alger BE (2001) DSI promotes LTP induction in CA1. Society for Neuroscience Abstracts 27
Varma N, Carlson GC, Ledent C, Alger BE (2001) Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus. J Neurosci 21: RC188
Varvel SA, Lichtman AH (2002) Evaluation of CB1 receptor knockout mice in the Morris water maze. J Pharmacol Exp Ther 301: 915-924
Vasquez C, Lewis DL (1999) The CB1 cannabinoid receptor can sequester G-proteins, making them unavailable to couple to other receptors. J Neurosci 19: 9271-9280
Vasquez C, Lewis DL (2003) The beta2-adrenergic receptor specifically sequesters Gs but signals through both Gs and Gi/o in rat sympathetic neurons. Neuroscience 118: 603-610
Vasquez C, Navarro-Polanco RA, Huerta M, Trujillo X, Andrade F, Trujillo-Hernandez B, Hernandez L (2003) Effects of cannabinoids on endogenous K+ and Ca2+ currents in HEK293 cells. Can J Physiol Pharmacol 81: 436-442
Vaughan CW, Connor M, Bagley EE, Christie MJ (2000) Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro. Mol Pharmacol 57: 288-295
Vaughan CW, McGregor IS, Christie MJ (1999) Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro. Br J Pharmacol 127: 935-940
Vela G, Ruiz-Gayo M, Fuentes JA (1995) Anandamide decreases naloxone-precipitated withdrawal signs in mice chronically treated with morphine. Neuropharmacology 34: 665-668
Velasco L, Ruiz L, Sanchez MG, Diaz-Laviada I (2001) delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1. Eur J Biochem 268: 531-535
Veldhuis WB, van der Stelt M, Wadman MW, van Zadelhoff G, Maccarrone M, Fezza F, Veldink GA, Vliegenthart JF, Bar PR, Nicolay K, Di Marzo V (2003) Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. J Neurosci 23: 4127-4133
Vellani V, Mapplebeck S, Moriondo A, Davis JB, McNaughton PA (2001) Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol 534: 813-825
Vellucci SV, Parrott RF (2000) Hippocampal gene expression in the pig: upregulation of corticotrophin releasing hormone mRNA following central administration of the peptide. Neuropeptides 34: 221-228
Vellucci SV, Parrott RF, Mimmack ML (2002) Chronic dexamethasone-treatment alters mineralocorticoid receptor, truncated trkB and selected glutamate receptor subunit mRNA expression in the porcine hippocampus. Neuropeptides 36: 291-298
Venance L, Maldonado R, Manzoni O (2004) [Endocannabinoids in the central nervous system]. Med Sci (Paris) 20: 45-53
Venance L, Piomelli D, Glowinski J, Giaume C (1995) Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature 376: 590-594
Venance L, Sagan S, Giaume C (1997) (R)-methanandamide inhibits receptor-induced calcium responses by depleting internal calcium stores in cultured astrocytes. Pflugers Arch 434: 147-149
Verca MSB, Marsicano G, Pagotto U, Fezza F, Milone A, Di Marzo V, Stalla G, Lutz B (2001) Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endocannabinoids. Society for Neuroscience Abstracts 27
Verma S, Hiby SE, Loke YW, King A (2000) Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15. Biol Reprod 62: 959-968
Verme JL, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D (2005) The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol 67: 15-19
Verrico CD, Jentsch JD, Dazzi L, Roth RH (2003) Systemic, but not local, administration of cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in the rat. Synapse 48: 178-183
Verty AN, McFarlane JR, McGregor IS, Mallet PE (2004) Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Endocrinology
Verty AN, McGregor IS, Mallet PE (2004) Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. Neurosci Lett 354: 217-220
Verty AN, Singh ME, McGregor IS, Mallet PE (2003) The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine. Psychopharmacology (Berl) 168: 314-323
Vickers SP, Webster LJ, Wyatt A, Dourish CT, Kennett GA (2003) Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. Psychopharmacology (Berl) 167: 103-111
Vidrio H, Sanchez-Salvatori MA, Medina M (1996) Cardiovascular effects of (-)-11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl in rats. J Cardiovasc Pharmacol 28: 332-336
Vigano D, Grazia Cascio M, Rubino T, Fezza F, Vaccani A, Di Marzo V, Parolaro D (2003) Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain. Neuropsychopharmacology 28: 1160-1167
Viggiano D, Ruocco LA, Pignatelli M, Grammatikopoulos G, Sadile AG (2003) Prenatal elevation of endocannabinoids corrects the unbalance between dopamine systems and reduces activity in the Naples High Excitability rats. Neurosci Biobehav Rev 27: 129-139
Viggiano D, Ruocco LA, Pignatelli M, Grammatikopoulos G, Sadile AG (2003) Prenatal elevation of endocannabinois corrects the unbalance between dopamine systems and reduces activity in the Naples High Excitability rats. Neuroscience and Biobehavioral Reviews 27: 129-139
Vigna SR (2003) Cannabinoids and the gut. Gastroenterology 125: 973-975
Vigorito E, Bell S, Hebeis BJ, Reynolds H, McAdam S, Emson PC, McKenzie A, Turner M (2004) Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol 24: 719-729
Vincent P (1992) Cationic channels sensitive to extracellular ATP in rat lacrimal cells. J Physiol 449: 313-331
Vindlacheruvu RR, Ebling FJ, Maywood ES, Hastings MH (1992) Blockade of Glutamatergic Neurotransmission in the Suprachiasmatic Nucleus Prevents Cellular and Behavioural Responses of the Circadian System to Light. Eur J Neurosci 4: 673-679
Vinklerova J, Novakova J, Sulcova A (2002) Inhibition of methamphetamine self-administration in rats by cannabinoid receptor antagonist AM 251. J Psychopharmacol 16: 139-143
Vinod KY, Kassir SA, Basavarajappa BS, Arango V, Mann JJ, Cooper TB, Hungund BL (2002) Upregulation of Cannabinoid Cb1 Receptors in the Prefrontal Cortex of Depressed Suicides. Society for Neuroscience Abstract Viewer and Itinerary Planner 2002
Vinos J, Freeman M (2000) Evidence that Argos is an antagonistic ligand of the EGF receptor. Oncogene 19: 3560-3562
Vivian JA, Kishioka S, Butelman ER, Broadbear J, Lee KO, Woods JH (1998) Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: antagonist effects of SR 141716A. J Pharmacol Exp Ther 286: 697-703
Vlachou S, Nomikos GG, Panagis G (2003) WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation. Behav Brain Res 141: 215-222
Vogel Z, Barg J, Levy R, Saya D, Heldman E, Mechoulam R (1993) Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J Neurochem 61: 352-355